Identification, isolation, structural characterisation, synthesis and <i>in silico</i> toxicity prediction of the alkaline hydrolytic degradation product of brivaracetam by using LC-PDA, preparative HPLC, LC/HESI/LTQ, FTIR, and <sup>1</sup>H NMR
Pankaj Bhamare, P. Umadoss, Neeraj Upmanyu, Rupal Dubey
Abstract
toxicity prediction was carried out by using the eMolTox webserver. The synthesis of isolated impurities of brivaracetam has also been carried out successfully.
Topics & Concepts
ChemistryDegradation (telecommunications)Alkaline hydrolysisLevetiracetamHigh-performance liquid chromatographyHydrolysisChromatographyDerivative (finance)Hydrolytic degradationOrganic chemistryEpilepsyFinancial economicsBiologyComputer scienceTelecommunicationsNeuroscienceEconomicsEpilepsy research and treatmentAntibiotics Pharmacokinetics and EfficacyPharmacological Effects and Toxicity Studies