Recent Advances in Reductive Desymmetrization of Diketones
Yi‐Xuan Ding, Zhou‐Hao Zhu, Chang‐Bin Yu, Yong‐Gui Zhou
Abstract
Abstract Reductive desymmetrization of achiral or meso diketones has attracted considerable attention due to these motifs which play important roles in organic synthesis, pharmaceuticals and functional materials. This review focuses on recent advances in homogeneous reductive desymmetrization of 1,2‐, 1,3‐ and 1,4‐diketones, which provides an efficient and practical access to structurally diverse chiral α‐, β‐ or γ‐hydroxy ketone derivatives.
Topics & Concepts
DesymmetrizationChemistryHomogeneousKetoneCombinatorial chemistryOrganic chemistryEnantioselective synthesisCatalysisThermodynamicsPhysicsAsymmetric Hydrogenation and CatalysisAsymmetric Synthesis and CatalysisAxial and Atropisomeric Chirality Synthesis