Increased LDL receptor by SREBP2 or SREBP2-induced lncRNA LDLR-AS promotes triglyceride accumulation in fish
Xiufei Cao, Wei Fang, Xueshan Li, Xiuneng Wang, Kangsen Mai, Qinghui Ai
Abstract
mRNA at the post-transcription level. In conclusion, our study demonstrates that increased LDLR transcription and mRNA stability is regulated by SREBP2 directly or indirectly, and promotes hepatic TG accumulation by endocytosing LDL in fish.
Topics & Concepts
LDL receptorTriglycerideFish <Actinopterygii>ChemistryCholesterolBiologyFisheryBiochemistryLipoproteinCancer-related molecular mechanisms researchPeroxisome Proliferator-Activated ReceptorsCholesterol and Lipid Metabolism