Whole tissue and single cell mechanics are correlated in human brain tumors
Frank Sauer, Anatol W. Fritsch, Steffen Grosser, Steve Pawlizak, T. Kießling, M Reiss-Zimmermann, Mehrgan Shahryari, Wolf Müller, Karl‐Titus Hoffmann, Josef A. Käs, Ingolf Sack
Abstract
emergent effects or cellular unjamming) of many cancer cells, which depend on cellular stiffness, influence the mechanical dissipation behavior of the bulk tissue. Our results are important to understand the emergent rheology of active multiscale compound materials such as brain tumors and its role in disease progression.
Topics & Concepts
Brain tissueBrain CellCellHuman brainMolecular mechanicsChemistryBiophysicsNeuroscienceBiologyComputational chemistryBiochemistryMolecular dynamicsCellular Mechanics and InteractionsCancer Cells and Metastasis3D Printing in Biomedical Research