Extended subsite profiling of the pyroptosis effector protein gasdermin D reveals a region recognized by inflammatory caspase-11
Betsaida Bibo‐Verdugo, Scott J. Snipas, Sonia Kołt, Marcin Poręba, Guy S. Salvesen
Abstract
caspase-4 and caspase-5, are ruled by the same mechanism. We propose that P1'-P4'-based inhibitors could be exploited to specifically target inflammatory caspases.
Topics & Concepts
PyroptosisEffectorInflammasomeCaspase 1Profiling (computer programming)SUPERFAMILYComputational biologyCell biologyBiologyChemistryInflammationGeneticsImmunologyReceptorComputer scienceOperating systemInflammasome and immune disordersGout, Hyperuricemia, Uric AcidStreptococcal Infections and Treatments