15-Lipoxygenase worsens renal fibrosis, inflammation, and metabolism in a murine model of ureteral obstruction
John R. Montford, Colin Bauer, Jeremy Rahkola, Julie A. Reisz, D C Floyd, Katharina Hopp, Danielle E. Soranno, Jelena Klawitter, Mary C.M. Weiser‐Evans, Raphael A. Nemenoff, Faubel Sarah, Seth B. Furgeson
Abstract
15-Lipoxygenase (15-LO) has both pro- and anti-inflammatory functions in leukocytes, and its role in kidney injury and repair is unexplored. Our study showed that 15-LO worsens inflammation and fibrosis in a rodent model of chronic kidney disease using genetic and pharmacological manipulation. Silencing 15-LO promotes an increase in M2c-like wound-healing macrophages in the kidney and alters kidney metabolism globally, protecting against anaerobic glycolysis after injury.
Topics & Concepts
InflammationFibrosisKidneyKidney diseaseGene silencingMedicineArachidonate 5-lipoxygenaseGlycolysisLipoxygenaseAcute kidney injuryCancer researchMetabolismPathologyBiologyImmunologyInternal medicineEnzymeBiochemistryGeneArachidonic acidEicosanoids and Hypertension PharmacologyAcute Kidney Injury ResearchChronic Kidney Disease and Diabetes