Gadolinium-based ultra-small nanoparticles augment radiotherapy-induced T-cell response to synergize with checkpoint blockade immunotherapy
Huijuan Song, Hao Sun, Ningning He, Chang Xu, Yan Wang, Liqing Du, Yang Liu, Qin Wang, Kaihua Ji, Jinhan Wang, Manman Zhang, Yeqing Gu, Yumin Zhang, Feng Li, Olivier Tillement, Weiwei Wang, Qiang Liu
Abstract
T cells and effective alleviation of the immunosuppressive tumor microenvironment. Our findings indicate that the synergy between radiosensitization and immunomodulation provides a new and powerful therapy regimen to achieve durable antitumor T-cell responses, which is promising for cancer treatment.
Topics & Concepts
BlockadeAugmentImmunotherapyCancer researchImmune checkpointGadoliniumRadiation therapyMedicineMaterials scienceImmunologyImmune systemInternal medicineReceptorPhilosophyLinguisticsMetallurgyCancer Immunotherapy and BiomarkersNanoplatforms for cancer theranosticsImmunotherapy and Immune Responses