Impact of sleep on chronobiology of micturition among healthy older adults
Shachi Tyagi, Neil M. Resnick, Becky Clarkson, Gehui Zhang, Robert T. Krafty, Subashan Perera, Arohan R. Subramanya, Daniel J. Buysse
Abstract
Nocturia (waking to void) is the most common cause of sleep interruption among older adults, and increased nighttime urine production is its primary etiology. We showed that in healthy older adults sleep affects the 24-h secretory rhythm of hormones that regulate salt-water balance, which potentially alters nighttime urine output. Further studies are needed to elucidate the impact of chronic insomnia on the secretory rhythms of these hormones.
Topics & Concepts
Circadian rhythmInternal medicineEndocrinologyAldosteroneMedicineHormonePlasma renin activityAntidiureticAtrial natriuretic peptideRhythmRenin–angiotensin systemBlood pressureCircadian rhythm and melatoninThermoregulation and physiological responsesUrinary Bladder and Prostate Research