Recent Development of 1,2,4-triazole-containing Compounds as Anticancer Agents
Xiaoyue Wen, Yong-qin Zhou, Junhao Zeng, Xinyue Liu
Abstract
1,2,4-Triazole derivatives possess promising in vitro and in vivo anticancer activity, and many anticancer agents such as fluconazole, tebuconazole, triadimefon, and ribavirin bear a 1,2,4-triazole moiety, revealing their potential in the development of novel anticancer agents. This review emphasizes the recent advances in 1,2,4-triazole-containing compounds with anticancer potential, and the structureactivity relationships as well as mechanisms of action are also discussed.
Topics & Concepts
TebuconazoleTriazoleChemistryFluconazoleTriadimefonIn vivoMoietyAntifungalPharmacologyCombinatorial chemistryBiologyStereochemistryFungicideBiotechnologyOrganic chemistryBotanyMicrobiologyClick Chemistry and ApplicationsSynthesis and biological activitySynthesis and Biological Evaluation