Notch-Regulated c-Kit–Positive Liver Sinusoidal Endothelial Cells Contribute to Liver Zonation and Regeneration
Juanli Duan, Ziyi Zhou, Bai Ruan, Zhiqiang Fang, Jian Ding, Jingjing Liu, Ping Song, Hao Xu, Xu Chen, Zhen‐Sheng Yue, Hua Han, Guo‐Rui Dou, Lin Wang
Abstract
BACKGROUND & AIMS: SECs, a newly identified subset of SECs in liver regeneration. METHODS: or quantitative polymerase chain reaction injection. RESULTS: SEC infusion attenuates toxin-induced liver injuries in mice. CONCLUSIONS: SECs contributes to liver zonation and regeneration through Wnt2 and is regulated by Notch signaling, providing opportunities for novel therapeutic approaches to liver injury in the future. Transcript profiling: GEO (accession number: GSE134037).
Topics & Concepts
Liver regenerationHepatocyteBiologyRegeneration (biology)Cell sortingHepatic stellate cellCell biologyMolecular biologyEndocrinologyIn vitroFlow cytometryBiochemistryLiver physiology and pathologyOrgan Transplantation Techniques and OutcomesCancer, Hypoxia, and Metabolism