Predictors for malignant potential and deep submucosal invasion in colorectal laterally spreading tumors
Xiaowen Hao, Peng Li, Yongjun Wang, Ming Ji, Shutian Zhang, Haiyun Shi
Abstract
BACKGROUND: resection by endoscopic submucosal dissection (ESD), but lesions with deep submucosal invasion (SMI) are endoscopically unresectable. AIM: To investigate the factors associated with high-grade dysplasia (HGD)/carcinoma and deep SMI in colorectal LSTs. METHODS: The endoscopic and histological results of consecutive patients who underwent ESD for colorectal LSTs in our hospital from June 2013 to March 2019 were retrospectively analyzed. The characteristics of LST subtypes were compared. Risk factors for HGD/carcinoma and deep SMI (invasion depth ≥ 1000 μm) were determined using multivariate logistic regression. RESULTS: = 0.007) were independent risk factors for deep SMI. CONCLUSION: through ESD. Given their substantial risk for deep SMI, surgery needs to be considered for NG-PD LSTs located in the rectosigmoid, especially those with positive non-lifting signs.