Synthesis of β-nitro ketones from geminal bromonitroalkanes and silyl enol ethers by visible light photoredox catalysis
Haoying Cao, Shanshan Ma, Yanhong Feng, Yawen Guo, Peng Jiao
Abstract
Various β-nitro ketones, including those bearing a β-tertiary carbon, were prepared from geminal bromonitroalkanes and trimethylsilyl enol ethers of a broad range of ketones by visible light photoredox catalysis, which were then easily converted into β-amino ketones, 1,3-amino alcohols, α,β-unsaturated ketones, β-cyano ketones and γ-nitro ketones.
Topics & Concepts
GeminalEnolSilylationNitroChemistryTrimethylsilylCatalysisOrganic chemistryKetonePhotoredox catalysisPhotochemistryMedicinal chemistryPhotocatalysisAlkylRadical Photochemical ReactionsSulfur-Based Synthesis TechniquesSynthesis and Catalytic Reactions