Iodine-Mediated Electrochemical C(sp<sup>2</sup>)–H Amination: Switchable Synthesis of Indolines and Indoles
Kangfei Hu, Yan Zhang, Zhenghong Zhou, Yu Yang, Zhenggen Zha, Zhiyong Wang
Abstract
A metal-free electrochemical intramolecular C(sp2)–H amination using iodine as a mediator was developed. This method enables a switchable synthesis of indoline and indole derivatives, respectively, from easily available 2-vinyl anilines.
Topics & Concepts
IndolineChemistryAminationIodineIntramolecular forceElectrochemistryIndole testCombinatorial chemistryOrganic chemistryCatalysisPhysical chemistryElectrodeCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsSynthesis and Catalytic Reactions