Inhibition of the NLRP3 inflammasome prevents ovarian aging
José M. Navarro‐Pando, Elísabet Alcocer‐Gómez, Beatriz Castejón‐Vega, Elena Navarro‐Villarán, Mónica Condés-Hervás, María Mundi-Roldan, Jordi Muntané, Antonio J. Pérez‐Pulido, Pedro Bullón, Chun Wang, Hal M. Hoffman, Alberto Sanz, Gabriel Mbalaviele, Bernhard Ryffel, Mario D. Cordero
Abstract
mice. These results suggest that the NLRP3 inflammasome is implicated in the age-dependent loss of female fertility and position this inflammasome as a potential new therapeutic target for the treatment of infertility.
Topics & Concepts
InflammasomeMedicineChemistryBiologyCell biologyImmunologyInflammationInflammasome and immune disordersEndometriosis Research and TreatmentReproductive System and Pregnancy