Improved correction of F508del-CFTR biogenesis with a folding facilitator and an inhibitor of protein ubiquitination
Jennifer L. Goeckeler-Fried, R. Aldrin Denny, Disha Joshi, Clare Hill, Mads Larsen, Annette Chiang, Raymond A. Frizzell, Peter Wipf, Eric J. Sorscher, Jeffrey L. Brodsky
Topics & Concepts
Cystic fibrosis transmembrane conductance regulatorUbiquitinChemistryBiogenesisProtein foldingProtein degradationProteasomeTransmembrane proteinBiochemistrySmall moleculeCell biologyBiologyReceptorGeneCystic Fibrosis Research AdvancesImmunodeficiency and Autoimmune DisordersGenetics and Neurodevelopmental Disorders