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Bromine-radical-induced C<sub>sp<sup>2</sup></sub>–H difluoroalkylation of quinoxalinones and hydrazones through visible-light-promoted C<sub>sp<sup>3</sup></sub>–Br bond homolysis

Chuan‐Hua Qu, Run Qiu Huang, Yuan Liu, Tong Liu, Gui‐Ting Song

2022Organic Chemistry Frontiers27 citationsDOI

Abstract

Bromine radicals derived from photo-induced C sp 3 –Br bond homolysis can mediate H abstraction/imine radical formation from quinoxalinones and hydrazones, which in turn quench the in situ -generated difluoroalkyl radicals to furnish the products.

Topics & Concepts

HomolysisChemistryRadicalBrominePhotochemistryMedicinal chemistryOrganic chemistryFluorine in Organic ChemistryRadical Photochemical ReactionsCatalytic C–H Functionalization Methods
Bromine-radical-induced C<sub>sp<sup>2</sup></sub>–H difluoroalkylation of quinoxalinones and hydrazones through visible-light-promoted C<sub>sp<sup>3</sup></sub>–Br bond homolysis | Litcius