The Regulatory Role of Ferroptosis in Bone Homeostasis
Yuan Xiong, Lang Chen, Ze Lin, Yiqiang Hu, Adriana C. Panayi, Wu Zhou, Yun Sun, Faqi Cao, Guodong Liu, Guangdong Dai, Bobin Mi, Guohui Liu
Abstract
Ferroptosis is an iron-dependent form of programmed cell death and an important type of biological catabolism. Through the action of divalent iron or ester oxygenase, ferroptosis can induce lipid peroxidation and cell death, regulating a variety of physiological processes. The role of ferroptosis in the modulation of bone homeostasis is a significant topic of interest. Herein, we review and discuss recent studies exploring the mechanisms and functions of ferroptosis in different bone-related cells, including mesenchymal stem cells, osteoblasts, osteoclasts, and osteocytes. The association between ferroptosis and disorders of bone homeostasis is also explored in this review. Overall, we aim to provide a detailed overview of ferroptosis, summarizing recent understanding on its role in regulation of bone physiology and bone disease pathogenesis.