Emerging SARS-CoV-2 variants of concern and potential intervention approaches
Jasmin Khateeb, Yuchong Li, Haibo Zhang
Abstract
The major variant of concerns (VOCs) have shared mutations in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike proteins, mostly on the S1 unit and resulted in higher transmissibility rate and affect viral virulence and clinical outcome. The spike protein mutations and other non-structural protein mutations in the VOCs may lead to escape approved vaccinations in certain extend. We will discuss these VOC mutations and discuss the need for combination therapeutic strategies targeting viral cycle and immune host responses.
Topics & Concepts
MedicineSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Transmissibility (structural dynamics)CoronavirusCoronavirus disease 2019 (COVID-19)Virulence2019-20 coronavirus outbreakMutationImmune systemSpike ProteinBioinformaticsVirologyIntensive care medicineGeneImmunologyGeneticsBiologyDiseaseOutbreakInternal medicineInfectious disease (medical specialty)Quantum mechanicsPhysicsVibrationVibration isolationSARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research StudiesViral gastroenteritis research and epidemiology