Long non-coding RNA MAFG-AS1 knockdown blocks malignant progression in breast cancer cells by inactivating JAK2/STAT3 signaling pathway via MAFG-AS1/miR-3196/TFAP2A axis.
Mingxing Ding, Yongqiang Fu, Fangming Guo, Haohao Chen, Xiaoyan Fu, Wen-zhuang Tan, Hui Zhang
Abstract
BACKGROUND: Breast cancer is still a leading threat to women's lives. Long non-coding RNAs (lncRNA) associated with cancer progression are getting attention. The objective of this study was to investigate the role of lncRNA MAFG-antisense 1 (MAFG-AS1) and mechanisms of action in breast cancer. METHODS: was determined by the tumor formation assay in nude mice. RESULTS: . CONCLUSION: through activation of the JAK2/STAT3 signaling pathway by the MAFG-AS1/miR-3196/TFAP2A regulatory axis.
Topics & Concepts
Gene knockdownBiologyCancer researchMolecular biologyLactate dehydrogenase ACell growthSTAT3Cyclin D1Cell cycleApoptosisSignal transductionCell biologyLactate dehydrogenaseBiochemistryEnzymeCancer-related molecular mechanisms researchRNA Research and SplicingCircular RNAs in diseases