Bcr-Abl drives the formation of Hsp70/Bim PPI to stabilize oncogenic clients and prevent cells from undergoing apoptosis
Hong Zhang, Ting Song, Ziqian Wang, Uwituze Laura Bonnette, Yafei Guo, Hang Wang, Qishuang Gao, Zhichao Zhang
Topics & Concepts
breakpoint cluster regionCancer researchABLProtein kinase BBiologyApoptosisTyrosine kinasePI3K/AKT/mTOR pathwayCell biologySignal transductionReceptorBiochemistryChronic Myeloid Leukemia TreatmentsChronic Lymphocytic Leukemia ResearchSynthesis and Biological Evaluation