Single point mutations can potentially enhance infectivity of SARS-CoV-2 revealed by <i>in silico</i> affinity maturation and SPR assay
Ting Xue, Weikun Wu, Ning Guo, Chengyong Wu, Jian Huang, Lipeng Lai, Hong Liu, Yalun Li, Tianyuan Wang, Yuxi Wang
Abstract
method as a powerful tool to forecast more powerful virus mutants, which will significantly benefit the development of broadly neutralizing vaccine and antibody.
Topics & Concepts
In silicoInfectivitySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Point mutationCoronavirus disease 2019 (COVID-19)Computational biologyChemistry2019-20 coronavirus outbreakVirologyMutationBiologyGeneticsVirusGeneMedicineDiseaseOutbreakInfectious disease (medical specialty)PathologySARS-CoV-2 and COVID-19 ResearchBacteriophages and microbial interactionsRNA Interference and Gene Delivery