Design, synthesis and evaluation of EZH2-based PROTACs targeting PRC2 complex in lymphoma
Huiru Xie, Wei Xu, Jing Liang, Yang Liu, Chenxi Zhuo, Xiaoxue Zou, Weihong Luo, Jianping Xiao, Lin Yu, Lixia Chen, Hua Li
Topics & Concepts
EZH2ChemistryUbiquitin ligasePRC2Mdm2DNA ligaseCancer researchMethylationUbiquitinCell cultureCell biologyBiochemistryDNABiologyGeneticsApoptosisGeneProtein Degradation and InhibitorsEpigenetics and DNA MethylationHistone Deacetylase Inhibitors Research