Plasminogen Activator Inhibitor-1–Positive Platelet-Derived Extracellular Vesicles Predicts MACE and the Proinflammatory SMC Phenotype
Richard G. Jung, Anne‐Claire Duchez, Trevor Simard, Shan Dhaliwal, Taylor Gillmore, Pietro Di Santo, Alisha Labinaz, F. Daniel Ramirez, Adil Rasheed, Sabrina Robichaud, Mireille Ouimet, Spencer Short, Cole Clifford, Fengxia Xiao, Marie Lordkipanidzé, Dylan Burger, Suresh Gadde, Katey J. Rayner, Benjamin Hibbert
Abstract
Patients with established coronary artery disease remain at elevated risk of major adverse cardiac events. The goal of this study was to evaluate the utility of plasminogen activator inhibitor-1-positive platelet-derived extracellular vesicles as a biomarker for major adverse cardiac events and to explore potential underlying mechanisms. Our study suggests these extracellular vesicles as a potential biomarker to identify and a therapeutic target to ameliorate neointimal formation of high-risk patients.