Utility of Intravenous Curcumin Nanodelivery Systems for Improving <i>In Vivo</i> Pharmacokinetics and Anticancer Pharmacodynamics
Mahsa Bagheri, Cornelus F. van Nostrum, Robbert J. Kok, Gert Storm, Wim E. Hennink, Michal Heger
Abstract
and CL. However, when the data were unpaired and clustered for comparative analysis, only 5 out of the 12 analyzed nanoformulations maintained a higher relative curcumin concentration in plasma over time compared to free curcumin. Quantitative analysis of the mean plasma concentration of free curcumin versus nanoformulated curcumin did not reveal an overall marked improvement in curcumin PK. No correlation was found between PK and PD, suggesting that augmentation of the systemic presence of curcumin does not necessarily lead to greater therapeutic efficacy.
Topics & Concepts
CurcuminPharmacokineticsPharmacologyCmaxPharmacodynamicsChemistryVolume of distributionIn vivoArea under the curveMedicineBiotechnologyBiologyCurcumin's Biomedical ApplicationsNanoparticle-Based Drug DeliveryAdvancements in Transdermal Drug Delivery