A chiral microenvironment promotes retinal progenitor cell proliferation by activating the Akt and ERK pathways
Na Sun, Jiajing Wang, Xiaoqiu Dou, Yiqi Wang, Yuan Yang, Dong Xiao, Peiquan Zhao, Jing Li, Shuting Wang, Ping Gu, Jing Ji
Abstract
the activation of the Akt and extracellular signal-regulated kinase (ERK) pathways. In addition, both LP and DP nanofibrous films have the advantage of attenuating inflammation, and LP films can maintain the stem potential of RPCs. Thus, the promotion of RPC proliferation using a bioinspired chiral fibrous microenvironment is a promising strategy for RPC-based therapies for retinal degeneration.
Topics & Concepts
Cell biologyMAPK/ERK pathwayChemistryProgenitor cellProtein kinase BCell growthSignal transductionRetinalStem cellBiologyBiochemistryPhotochromic and Fluorescence ChemistryNanoplatforms for cancer theranosticsCell Adhesion Molecules Research