Coordination effect enabled palladium-catalyzed regioselective <i>O</i>-alkylation of 2-pyridones
Zhiqiang Lu, Yanzhi Li, Yi Ru, Shujian Yang, Chu Hao, Mengke Zuo, Rongkai Jiao, Weilong Wu, Yan Zhou, Hui Yao, Nianyu Huang, Yuqin Fu
Abstract
A novel tactic for the regioselective O -alkylation of 2-pyridones has been realized through palladium catalysis facilitated by silver carbonate in moderate to high yields, the coordination effect between palladium and nitrogen on the pyridine ring plays a versatile role.
Topics & Concepts
RegioselectivityPalladiumCatalysisAlkylationChemistryPyridineRing (chemistry)Medicinal chemistryCombinatorial chemistryOrganic chemistryCatalytic C–H Functionalization MethodsAsymmetric Synthesis and CatalysisCatalytic Cross-Coupling Reactions