The full spectrum of SLC22 OCT1 mutations illuminates the bridge between drug transporter biophysics and pharmacogenomics
Sook Wah Yee, Christian B. Macdonald, Darko Mitrovic, Xujia Zhou, Megan L. Koleske, Jia Yang, Dina Buitrago Silva, Patrick Rockefeller Grimes, Donovan Trinidad, Swati S. More, Linda Kachuri, John S. Witte, Lucie Delemotte, Kathleen M. Giacomini, Willow Coyote‐Maestas
Topics & Concepts
BiologyMissense mutationMutagenesisComputational biologyPharmacogenomicsTransporterPhenotypeGeneticsFunctional genomicsSaturated mutagenesisOrganic cation transport proteinsSolute carrier familyMutationGeneGenomicsGenomeMutantDrug Transport and Resistance MechanismsHIV/AIDS drug development and treatmentAmino Acid Enzymes and Metabolism