Link between glucose metabolism and epithelial-to-mesenchymal transition drives triple-negative breast cancer migratory heterogeneity
Samantha C. Schwager, Jenna A. Mosier, Reethi S. Padmanabhan, Addison White, Qinzhe Xing, Lauren A. Hapach, Paul Taufalele, Ismael Ortiz, Cynthia A. Reinhart‐King
Abstract
can be made more glycolytic, mesenchymal, and migratory via modulation of glucose metabolism or EMT. These findings reveal an intrinsic link between EMT and glucose metabolism that controls migration. Identifying mechanisms fueling phenotypic heterogeneity is essential to develop targeted metastatic therapeutics.
Topics & Concepts
GlycolysisEpithelial–mesenchymal transitionMesenchymal stem cellOxidative phosphorylationCell biologyPhenotypeBiologyCell migrationCancer cellIntracellularMetastasisMetabolismCellCancerBiochemistryGeneticsGeneCancer Cells and MetastasisCancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer