Formulation of intranasal surface engineered nanostructured lipid carriers of rotigotine: Full factorial design optimization, in vitro characterization, and pharmacokinetic evaluation
Ameeduzzafar Zafar, Omar Awad Alsaidan, Nabil K. Alruwaili, Syed Sarim Imam, Mohd Yasir, Khalid Saad Alharbi, Lubhan Singh, Mohammed Muqtader Ahmed
Topics & Concepts
BioavailabilityNasal administrationZeta potentialPharmacologyPharmacokineticsChemistryFactorial experimentPermeationParticle sizeBox–Behnken designSonicationIn vivoChromatographyDosage formMaterials scienceResponse surface methodologyNanotechnologyMedicineNanoparticleBiochemistryMembraneMathematicsBiologyStatisticsPhysical chemistryBiotechnologyAdvanced Drug Delivery SystemsLipid Membrane Structure and BehaviorAdvancements in Transdermal Drug Delivery