Highly mutated antibodies capable of neutralizing N276 glycan-deficient HIV after a single immunization with an Env trimer
Jeong Hyun Lee, Catherine Nakao, Michael Y. Appel, Amber Le, Elise Landais, Oleksandr Kalyuzhniy, Xiaozhen Hu, Alessia Liguori, Tina-Marie Mullen, Bettina Gröschel, Robert Abbott, Devin Sok, William R. Schief, Shane Crotty
Abstract
antibodies robustly bind N276 glycan-deficient Env trimers and neutralize several N276 glycan-deficient tier 2 HIV strains. These results are encouraging for GT Env trimer vaccine designs and demonstrate accumulation of substantial SHMs, including deletions, uncommon point mutations, and functional bnAb features, after a single immunization.
Topics & Concepts
Germinal centerGlycanAntibodyTrimerVirologyHIV vaccineGp41B cellBiologyAffinity maturationNaive B cellGermlineMemory B cellGlycoproteinCell biologyMolecular biologyImmunologyT cellChemistryGeneticsImmune systemEpitopeAntigen-presenting cellGeneDimerVaccine trialOrganic chemistryHIV Research and TreatmentImmune Cell Function and InteractionT-cell and B-cell Immunology