Activity of <i>N</i> -Acetylcysteine Alone and in Combination with Colistin against Pseudomonas aeruginosa Biofilms and Transcriptomic Response to <i>N</i> -Acetylcysteine Exposure
Felice Valzano, Selene Rebecca Boncompagni, Maria Micieli, Tiziana Di Maggio, Vincenzo Di Pilato, Lorenzo Colombini, Francesco Santoro, Gianni Pozzi, Gian María Rossolini, Lucia Pallecchi
Abstract
Pseudomonas aeruginosa biofilm-related chronic lung colonization contributes to cystic fibrosis (CF) disease progression. Colistin is often a last-resort antibiotic for the treatment of such P. aeruginosa infections, and it has been increasingly used in CF, especially by nebulization. N -acetylcysteine (NAC) is a mucolytic agent with antioxidant activity, commonly administered with antibiotics for the treatment of lower respiratory tract infections.
Topics & Concepts
ColistinPseudomonas aeruginosaAcetylcysteineAntibioticsCystic fibrosisBiofilmMicrobiologyMedicineBiologyBacteriaInternal medicineAntioxidantBiochemistryGeneticsBacterial biofilms and quorum sensingCystic Fibrosis Research AdvancesAntimicrobial Peptides and Activities