Association of Enlarged Perivascular Spaces and Measures of Small Vessel and Alzheimer Disease
Eske Christiane Gertje, Danielle van Westen, Clara Panizo, Niklas Mattsson, Oskar Hansson
Abstract
OBJECTIVE: To investigate the relationship between enlarged perivascular spaces (EPVS) and measures of Alzheimer disease (AD), small vessel disease (SVD), cognition, vascular risk factors, and neuroinflammation, we tested associations between EPVS and different relevant neuroimaging, biochemical, and cognitive variables in 778 study participants. METHODS: F]-flutemetamol PET; and vascular risk factors and results from cognitive tests were determined and collected. RESULTS: , total tau and phosphorylated tau, neuroinflammatory markers, vascular risk factors, and cognitive tests. EPVS in HP were associated with hippocampal atrophy. In a matched group of individuals with AD and CU, EPVS in HP were associated with AD diagnosis. CONCLUSIONS: EPVS are related to SVD, also in early disease stages, but the lack of correlation with cognition suggests that their importance is limited. Our data do not support a role for EPVS in early AD pathogenesis.