Oncolytic adenovirus targeting TGF-β enhances anti-tumor responses of mesothelin-targeted chimeric antigen receptor T cell therapy against breast cancer
Yuxiang Li, Fengjun Xiao, Aimei Zhang, Dan Zhang, Wenbo Nie, Tianxin Xu, Bing Han, Prem Seth, Hua Wang, Yuefeng Yang, Lisheng Wang
Topics & Concepts
Chimeric antigen receptorMesothelinCancer researchOncolytic virusTumor microenvironmentBreast cancerTargeted therapyImmunotherapyAntigenCancerMedicineImmunologyBiologyImmune systemInternal medicineTumor cellsCAR-T cell therapy researchVirus-based gene therapy researchNanowire Synthesis and Applications