Predictive and diagnostic utility of brief neuropsychological assessment in detecting Alzheimer’s pathology and progression to dementia.
Ingvild Vøllo Eliassen, Tormod Fladby, Bjørn‐Eivind Kirsebom, Knut Waterloo, Marie Eckerström, Anders Wallin, Geir Bråthen, Dag Aarsland, Erik Hessen
Abstract
Defining MCI using a brief neuropsychological battery provided limited accuracy for progression to AD dementia and cerebrospinal fluid Aβ. The lenient amnestic MCI criterion identified the highest number of individuals who progressed to clinical AD or showed biomarker pathology, but this approach included a substantial number of false positives. (PsycInfo Database Record (c) 2020 APA, all rights reserved).
Topics & Concepts
DementiaNeuropsychologyPsychologyInternal medicineAlzheimer's diseaseLogistic regressionNeuropsychological assessmentLumbar punctureCognitive impairmentMedicinePsychiatryOncologyCognitionPathologyCerebrospinal fluidDiseaseDementia and Cognitive Impairment Research