X-rays minibeam radiation therapy at a conventional irradiator: Pilot evaluation in F98-glioma bearing rats and dose calculations in a human phantom
Marios Sotiropoulos, Élise Brisebard, Marine Le Dudal, Grégory Jouvion, Marjorie Juchaux, Delphine Crépin, Catherine Sebrié, Laurène Jourdain, Dalila Labiod, Charlotte Lamirault, Frédéric Pouzoulet, Yolanda Prezado
Abstract
Minibeam radiation therapy (MBRT) is a type of spatial fractionated radiotherapy that uses submillimetric beams. This work reports on a pilot study on normal tissue response and the increase of the lifespan of glioma-bearing rats when irradiated with a tabletop x-ray system. Our results show a significant widening of the therapeutic window for brain tumours treated with MBRT: an important proportion of long-term survivals (60%) coupled with a significant reduction of toxicity when compared with conventional (broad beam) irradiations. In addition, the clinical translation of the minibeam treatment at a conventional irradiator is evaluated through a possible human head treatment plan.