Synthesis of 2,3-dihydrobenzo[b][1,4]dioxine-5-carboxamide and 3-oxo-3,4-dihydrobenzo[b][1,4]oxazine-8-carboxamide derivatives as PARP1 inhibitors
Xuwei Shao, Steven Pak, Uday Kiran Velagapudi, Shruthi Gobbooru, Sai Shilpa Kommaraju, Woon‐Kai Low, Gopal Subramaniam, Sanjai K. Pathak, Tanaji T. Talele
Topics & Concepts
CarboxamideChemistryPharmacophoreStereochemistryPARP1Virtual screeningBenzimidazoleLead compoundIC50Poly ADP ribose polymerasePolymeraseDNABiochemistryIn vitroOrganic chemistryPARP inhibition in cancer therapyDNA Repair MechanismsToxin Mechanisms and Immunotoxins