Litcius/Paper detail

Synthesis of 2,3-dihydrobenzo[b][1,4]dioxine-5-carboxamide and 3-oxo-3,4-dihydrobenzo[b][1,4]oxazine-8-carboxamide derivatives as PARP1 inhibitors

Xuwei Shao, Steven Pak, Uday Kiran Velagapudi, Shruthi Gobbooru, Sai Shilpa Kommaraju, Woon‐Kai Low, Gopal Subramaniam, Sanjai K. Pathak, Tanaji T. Talele

2020Bioorganic Chemistry12 citationsDOIOpen Access PDF

Topics & Concepts

CarboxamideChemistryPharmacophoreStereochemistryPARP1Virtual screeningBenzimidazoleLead compoundIC50Poly ADP ribose polymerasePolymeraseDNABiochemistryIn vitroOrganic chemistryPARP inhibition in cancer therapyDNA Repair MechanismsToxin Mechanisms and Immunotoxins