LOXL2-enriched small extracellular vesicles mediate hypoxia-induced premetastatic niche and indicates poor outcome of head and neck cancer
Guiquan Zhu, Linlin Wang, Wanrong Meng, Shun Lu, Bangrong Cao, Xin‐hua Liang, Chuanshi He, Yaying Hao, Xueyu Du, Xiaoyi Wang, Longjiang Li, Ling Li
Abstract
: sEVs derived from the hypoxic tumor microenvironment of HNSCC can drive local invasion of non-hypoxic HNSCC cells and stimulate premetastatic niche formation by delivering LOXL2 to non-hypoxic HNSCC cells and fibroblasts to induce EMT and fibronectin production, respectively.
Topics & Concepts
Extracellular vesiclesHypoxia (environmental)NicheExtracellularCell biologyTumor microenvironmentExtracellular vesicleVesicleHead and neckChemistryHead and neck cancerBiologyCancerCancer researchTumor cellsMicrovesiclesGeneMedicineBiochemistrymicroRNAGeneticsOxygenMembraneOrganic chemistrySurgeryExtracellular vesicles in diseaseRedox biology and oxidative stressRNA modifications and cancer