The shared susceptibility epitope of HLA-DR4 binds citrullinated self-antigens and the TCR
Jia Jia Lim, Claerwen M. Jones, Tiing Jen Loh, Yi Tian Ting, Pirooz Zareie, Khai Lee Loh, Nathan Felix, Anish Suri, Murray McKinnon, Frederik Stevenaert, Ravi Sharma, Lars Klareskog, Vivianne Malmström, Daniel G. Baker, Anthony W. Purcell, Hugh H. Reid, Nicole L. La Gruta, Jamie Rossjohn
Abstract
Citrullination of a fibrinogen peptide influences HLA-DR4 binding and TCR usage by neoepitope-reactive T cells in rheumatoid arthritis.
Topics & Concepts
CitrullinationEpitopeT-cell receptorImmunologyHuman leukocyte antigenMajor histocompatibility complexRheumatoid arthritisAntigenBiologyChemistryImmune systemT cellGeneticsCitrullineAmino acidArginineCell Adhesion Molecules ResearchT-cell and B-cell ImmunologySystemic Lupus Erythematosus Research