Intratumoral synthesis of transformable metal-phenolic nanoaggregates with enhanced tumor penetration and retention for photothermal immunotherapy
Xianglian He, Hongfu Zhu, Jiaojiao Shang, Meifeng Li, Yaoyao Zhang, Shicheng Zhou, Guidong Gong, Yunxiang He, Anna Blocki, Junling Guo
Abstract
Rationale: Effective photothermal therapy (PTT) remains a great challenge due to the difficulties of delivering photothermal agents with both deep penetration and prolonged retention at tumor lesion spatiotemporally. Methods: Here, we report an intratumoral self-assembled nanostructured aggregate named FerH, composed of a natural polyphenol and a commercial iron supplement. FerH assemblies possess size-increasing dynamic kinetics as a pseudo-stepwise polymerization from discrete nanocomplexes to microscale aggregates.
Topics & Concepts
Photothermal therapyPenetration (warfare)In vivoChemistryImmunotherapyCancer researchNanotechnologyMaterials scienceCancerMedicineBiologyBiotechnologyEngineeringOperations researchInternal medicineNanoplatforms for cancer theranosticsNanoparticle-Based Drug DeliveryExtracellular vesicles in disease