The impact of the physical state and the reaction phase in the direct mechanocatalytic Suzuki–Miyaura coupling reaction
Kwangho Yoo, Sven Fabig, Sven Grätz, Lars Borchardt
Abstract
compounds, was observed. In order to overcome the general low reactivity of the solid phase, several liquid-assisted grinding experiments were conducted and the influence of substrate solubility and catalyst wettability analyzed. Among all LAG additives, EtOH showed the greatest impact on the reactivity, as it converts boronic acid derivatives into liquid and reactive esters under mechanochemical conditions, significantly speeding up the reaction.
Topics & Concepts
Reactivity (psychology)ArylChemistrySteric effectsCatalysisReagentSubstrate (aquarium)Coupling reactionBoronic acidPalladiumPhase (matter)Suzuki reactionSolubilityCombinatorial chemistryOrganic chemistryChemical engineeringAlkylGeologyPathologyMedicineEngineeringAlternative medicineOceanographyCatalytic Cross-Coupling ReactionsChemical synthesis and alkaloidsCoordination Chemistry and Organometallics