PARP Inhibitor Applicability: Detailed Assays for Homologous Recombination Repair Pathway Components
Geraldine O'Sullivan Coyne, Chris Karlovich, Deborah Wilsker, Andrea Regier Voth, Ralph E Parchment, Alice P Chen, James H Doroshow
Abstract
Abstract: Poly(ADP-ribose) polymerase inhibitors (PARPi) have been in clinical use since 2014 for certain patients with germline BRCA1/2 mutations, but as evidence and approvals for their use in a wider range of patients grow, the question of how best to identify patients who would benefit from PARPi becomes ever more complex. Here, we discuss the development and current state of approved selection testing for PARPi therapy and the ongoing efforts to define a broader range of homologous recombination repair deficiencies that are susceptible to PARP inhibition. Keywords: next-generation sequencing, genomic scar, mutational signature, Rad51, BRCAness