Strasseriolides A–D, A Family of Antiplasmodial Macrolides Isolated from the Fungus <i>Strasseria geniculata</i> CF-247251
Frederick Annang, Guiomar Pérez‐Moreno, Víctor González-Menéndez, Rodney Lacret, Ignacio Pérez‐Victoria, Jesús Martı́n, Juan Cantizani, Nuria de Pedro, Duane Choquesillo‐Lazarte, Luis M. Ruiz‐Pérez, Dolores González‐Pacanowska, Olga Genilloud, Francisca Vicente, Fernando Reyes
Abstract
A novel family of four potent antimalarial macrolides, strasseriolides A–D (1–4), has been isolated from cultures of Strasseria geniculata CF-247251, a fungal strain obtained from plant tissues. The structures of these compounds, including their absolute configurations, were elucidated by HRMS, NMR spectroscopy, and X-ray single-crystal diffraction. The four compounds gave respective IC50 values of 9.810, 0.013, 0.123, and 0.128 μM against Plasmodium falciparum 3D7 parasites with no significant cytotoxicity against the HepG2 cell line.