New Xanthones with Antiagricultural Fungal Pathogen Activities from the Endophytic Fungus <i>Diaporthe goulteri</i> L17
Xiao-Ping Peng, Fusheng Sun, Gang Li, Cong Wang, Yuhan Zhang, Changzheng Wu, Chun‐yang Zhang, Yong Sun, Siyi Wu, Yuxiang Zhang, Hui Zong, Rui Guo, Hong‐Xiang Lou
Abstract
Six new xanthone dimers, diaporxanthones A–F (1–6), and an unusual xanthone monomer diaporxanthone G (7), in addition to seven known analogues (8–14), were isolated and identified from endophytic Diaporthe goulteri L17 harbored in the fruits of the salt-tolerant plant Vitex trifolia. The chemical structures of these metabolites were elucidated on the basis of nuclear magnetic resonance, high-resolution electrospray ionization mass spectrometry, and reported data in the literature. Their absolute configurations were established by single-crystal X-ray diffraction analysis together with time-dependent density functional theory electronic circular dichroism calculations. Among these compounds, compounds 1 and 6 exhibited moderate antifungal activities against Nectria sp. and Colletotrichum musae and compound 4 showed significant cytotoxicity against all selected five cancer cell lines.