From organoid culture to manufacturing: technologies for reproducible and scalable organoid production
Dohui Kim, Jaeseung Youn, Juhyeok Kim, Jeongmin Lee, Jangwon Yoon, Dong Sung Kim
Abstract
In this review, we systematically categorize diverse organoid engineering strategies-including cellular programming, material engineering, and platform- or system-level innovations-according to their impact on reproducibility and scalability, and highlight representative applications and emerging directions. By reframing organoid generation as a manufacturing process, these technological advances pave the way toward standardized and high-fidelity organoid production for both fundamental research and translational applications.
Topics & Concepts
OrganoidComputer scienceScalabilityComputational biologyCognitive reframingProduction (economics)Translational researchBiologyNanotechnologyCell biology3D Printing in Biomedical ResearchCancer Cells and MetastasisPluripotent Stem Cells Research