Understanding the Role of Endothelial Cells in Glioblastoma: Mechanisms and Novel Treatments
Gabrielle Hovis, Neha Chandra, Nidhi Kejriwal, Kaleb Jia-Yi Hsieh, Alison Chu, Isaac Yang, Madhuri Wadehra
Abstract
Glioblastoma is a highly aggressive neoplasm and the most common primary malignant brain tumor. Endothelial tissue plays a critical role in glioblastoma growth and progression, facilitating angiogenesis, cellular communication, and tumorigenesis. In this review, we present an up-to-date and comprehensive summary of the role of endothelial cells in glioblastomas, along with an overview of recent developments in glioblastoma therapies and tumor endothelial marker identification.
Topics & Concepts
GlioblastomaAngiogenesisCarcinogenesisBrain tumorCancer researchTumor progressionBiologyNeoplasmGliomaPathologyMedicineCancerGeneticsMicroRNA in disease regulationGlioma Diagnosis and TreatmentExtracellular vesicles in disease