New quinazoline-[1,2,4]triazolo[3,4- <i>b</i> ][1,3,4]thiadiazines as inhibitors of EGFR: synthesis, anti-breast cancer evaluation and <i>in silico</i> studies
Mahadev Dattatray Bandgar, Sampath Peddapelli, Ravikumar Kapavarapu, Joshodeep Boruwa, Sridhar Kavela, Sirassu Narsimha
Abstract
molecular docking investigations using the Discovery Studio 2021 methodology.
Topics & Concepts
PharmacophoreErlotinibBreast cancerEGFR inhibitorsIn silicoIC50In vitroChemistryLapatinibCancer cell linesQuinazolineCancerDocking (animal)PharmacologyCell cultureCancer researchCancer cellMedicineStereochemistryTrastuzumabEpidermal growth factor receptorBiochemistryBiologyInternal medicineGeneticsGeneNursingQuinazolinone synthesis and applicationsSynthesis and Biological EvaluationCancer therapeutics and mechanisms