Cell nucleus localization and high anticancer activity of quinoline–benzopyran rhodium(<scp>iii</scp>) metal complexes as therapeutic and fluorescence imaging agents
Zhenfeng Wang, Xiao-Ling Nai, Yue Xu, Feng-Hua Pan, Fu-Shun Tang, Qi‐Pin Qin, Lin Yang, Shu‐Hua Zhang
Abstract
RhQ can be used to target DNA as a highly anticancer therapeutic and fluorescence imaging agent. Importantly, RhQ exhibited significantly more potency than RhS and cisplatin.
Topics & Concepts
RhodiumQuinolineFluorescenceChemistryNucleusBenzopyranMetalBiochemistryCombinatorial chemistryBiophysicsStereochemistryCell biologyOrganic chemistryBiologyCatalysisPhysicsQuantum mechanicsMetal complexes synthesis and propertiesClick Chemistry and ApplicationsSynthesis and biological activity