Gold(<scp>i</scp>)-catalyzed redox transformation of <i>o</i>-nitroalkynes with indoles for the synthesis of 2,3′-biindole derivatives
Su Zhou, Qianqian Liu, Ming Bao, Jie Huang, Junjian Wang, Wenhao Hu, Xinfang Xu
Abstract
A gold(<sc>i</sc>)-catalyzed cascade reaction of <italic>o</italic>-nitroalkynes with indoles has been reported for the rapid assembly of 2-indolyl indolone <italic>N</italic>-oxides, which exhibit high anticancer potency against SCLC cells.
Topics & Concepts
ChemistryRedoxPotencyCatalysisCombinatorial chemistryStereochemistryIndole testMedicinal chemistryOrganic chemistryIn vitroBiochemistryCatalytic C–H Functionalization MethodsCatalytic Alkyne ReactionsCyclopropane Reaction Mechanisms