TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation
Katharina Fitzian, Anne Brückner, Laura Brohée, Reinhard Zech, Claudia Antoni, Stephan Kiontke, Raphael Gasper, Anna Lívia Linard Matos, Stephanie Beel, Sabine Wilhelm, Volker Gerke, Christian Ungermann, Mark Nellist, Stefan Raunser, Constantinos Demetriades, Andrea Oeckinghaus, Daniel Kümmel
Topics & Concepts
RHEBTSC1mTORC1GTPaseCell biologyBiologySmall GTPaseTSC2RegulatorFunction (biology)Protein subunitBiochemistrySignal transductionPI3K/AKT/mTOR pathwayGeneCellular transport and secretionPI3K/AKT/mTOR signaling in cancerProtein Kinase Regulation and GTPase Signaling