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AIM2 inflammasome mediates hallmark neuropathological alterations and cognitive impairment in a mouse model of vascular dementia

Luting Poh, David Y. Fann, Peiyan Wong, Hong Meng Lim, Sok Lin Foo, Sung-Wook Kang, Vismitha Rajeev, Sharmelee Selvaraji, Vinaya Rajagopal Iyer, Nageiswari Parathy, Mohammad Badruzzaman Khan, David C. Hess, Dong‐Gyu Jo, Grant R. Drummond, Christopher G. Sobey, Mitchell K.P. Lai, Christopher Chen, Lina H. K. Lim, Thiruma V. Arumugam

2020Molecular Psychiatry165 citationsDOI

Topics & Concepts

InflammasomePyroptosisAIM2NeuroscienceProinflammatory cytokineNeuroinflammationHippocampal formationMedicineCognitive declineInflammationDementiaImmunologyBiologyPathologyDiseaseNeurological Disease Mechanisms and TreatmentsInflammasome and immune disordersNeuroinflammation and Neurodegeneration Mechanisms
AIM2 inflammasome mediates hallmark neuropathological alterations and cognitive impairment in a mouse model of vascular dementia | Litcius